Inflammation and Immunity

This UK-wide research program aims to better understand the fundamental mechanisms of inflammation and immunity to deliver key insights and improve patient care for those affected by inflammation-mediated diseases.

Inflammation-mediated diseases present a global healthcare challenge, causing a significant adverse impact on individuals’ quality of life and a substantial economic strain on healthcare systems.

The Inflammation and Immunity Research Driver Programme will explore inflammation and immunity as general underpinning mechanisms, initially focusing on highly prevalent respiratory and allergic diseases. These conditions can be exacerbated by acute inflammatory episodes due to viral infections and environmental factors such as pollution, tobacco, pollen, weather, drugs, foods, stinging insects, etc.

This program aims to improve understanding and management of common respiratory and allergic diseases. It will track disease patterns, identify and address variations in care, and develop new tools for risk prediction using diverse data sources like genetics and wearables. The program will then evaluate these tools through large-scale trials and share its findings with the data science and global respiratory research communities.

Professor Gwyneth Davies, Programme Lead based in HDR UK Wales, said:

“I am thrilled to be involved in the HDR UK Driver programme on Inflammation and Immunity. This collaborative effort across the UK will provide key insights into respiratory conditions and use this learning for other inflammatory diseases. We are particularly interested in how this research translates into improved patient care for individuals suffering from inflammation-mediated diseases. In Wales, we have areas of high deprivation and we have a particular focus on targeting inequalities in care and outcomes here.

These conditions not only impact individuals’ quality of life but also place a substantial strain on healthcare systems. By focusing on highly prevalent respiratory and allergic diseases, the programme can address common triggers like viral infections and environmental factors, ultimately leading to better disease management and improved health outcomes.”

Driver Programme Team based in HDR UK Wales
  • Professor Gwyneth Davies
  • Chris Orton
  • Mohammad
  • Cedric Burden (PhD student)